Antimony trisulfide should never be used in any mixture containing chlorates, or else spontaneous ignition may occur. Mixtures with antimony trisulfide and perchlorates are very sensitive to friction and shock, and extra caution should be exercised when handling these mixtures. These mixtures are best avoided entirely. Wear proper protective clothing, including a dust mask and gloves, when working with compositions containing antimony trisulfide as it is very poisonous, and toxic to the kindnys and liver. Toxicity: ORAL (LD50): Acute: 7000 mg/kg [Rat] IPR-MUS LD50: 209 mg/kg. Most Antimony trisulphide that has been mined will contain a small Arsenic impurity which can contribute to toxicity depending on levels. At levels above 0.5% the material is classified as hazardous for shipping by air (IATA regulations 2010).